A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.
Spatial Discontinuities In Human-Immunodeficiency-Virus Type-1 Quasi-Species Derived From Epidermal Langerhans Cells Of A Patient With Aids And Evidence For Double Infection / M., Sala; G., Zambruno; J. P., Vartanian; Marconi, Alessandra; U., Bertazzoni; S., Wain Hobson. - In: JOURNAL OF VIROLOGY. - ISSN 0022-538X. - STAMPA. - 68:(1994), pp. 5280-5283.
Spatial Discontinuities In Human-Immunodeficiency-Virus Type-1 Quasi-Species Derived From Epidermal Langerhans Cells Of A Patient With Aids And Evidence For Double Infection
MARCONI, Alessandra;
1994
Abstract
A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.
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