Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis is unknown. Status epilepticus inducestemporal lobe epileptogenesis following a latent period in which glial cells are activated. Here, we found that P450scc, the rate-limiting enzyme insteroid synthesis, is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. More prolonged SE wasassociated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retardsepileptogenesis. The 5alpha-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derivedneurosteroids may be antiepileptogenic.

Neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy / Longo, Daniela; Baldelli, Enrica; L., Pradelli; Zini, Isabella; M. A., Rogawski; M., Avoli; Biagini, Giuseppe. - In: CLINICAL NEUROPATHOLOGY. - ISSN 0722-5091. - STAMPA. - 25:(2006), pp. 148-148. ((Intervento presentato al convegno 42nd Annual Meeting of the AINP - 32nd Meeting of the AIRIC tenutosi a Roma nel 24-27 maggio 2006.

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