By analyzing the functional role of adenosine receptor heteromers, we review a series of new concepts that should modify our classical views of neurotransmission in the central nervous system (CNS). Neurotransmitter receptors cannot be considered as single functional units anymore. Heteromerization of neurotransmitter receptors confers functional entities that possess different biochemical characteristics with respect to the individual components of the heteromer. Some of these characteristics can be used as a “biochemical fingerprint†to identify neurotransmitter receptor heteromers in the CNS. This is exemplified by changes in binding characteristics that are dependent on coactivation of the receptor units of different adenosine receptor heteromers. Neurotransmitter receptor heteromers can act as “processors†of computations that modulate cell signaling, sometimes critically involved in the control of pre- and postsynaptic neurotransmission. For instance, the adenosine A1-A2A receptor heteromer acts as a concentration-dependent switch that controls striatal glutamatergic neurotransmission. Neurotransmitter receptor heteromers play a particularly important integrative role in the “local module†(the minimal portion of one or more neurons and/or one or more glial cells that operates as an independent integrative unit), where they act as processors mediating computations that convey information from diverse volume-transmitted signals. For instance, the adenosine A2A-dopamine D2 receptor heteromers work as integrators of two different neurotransmitters in the striatal spine module.

Adenosine Receptor Heteromers and their Integrative Role in Striatal Function / S., Ferré; F., Ciruela; C., Quiroz; R., Luján; P., Popoli; R. A., Cunha; Agnati, Luigi Francesco; K., Fuxe; A. S., Woods; C., Lluis; R., Franco. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - STAMPA. - 7:2(2007), pp. 74-85. [10.1100/tsw.2007.211]

Adenosine Receptor Heteromers and their Integrative Role in Striatal Function

AGNATI, Luigi Francesco;
2007

Abstract

By analyzing the functional role of adenosine receptor heteromers, we review a series of new concepts that should modify our classical views of neurotransmission in the central nervous system (CNS). Neurotransmitter receptors cannot be considered as single functional units anymore. Heteromerization of neurotransmitter receptors confers functional entities that possess different biochemical characteristics with respect to the individual components of the heteromer. Some of these characteristics can be used as a “biochemical fingerprint†to identify neurotransmitter receptor heteromers in the CNS. This is exemplified by changes in binding characteristics that are dependent on coactivation of the receptor units of different adenosine receptor heteromers. Neurotransmitter receptor heteromers can act as “processors†of computations that modulate cell signaling, sometimes critically involved in the control of pre- and postsynaptic neurotransmission. For instance, the adenosine A1-A2A receptor heteromer acts as a concentration-dependent switch that controls striatal glutamatergic neurotransmission. Neurotransmitter receptor heteromers play a particularly important integrative role in the “local module†(the minimal portion of one or more neurons and/or one or more glial cells that operates as an independent integrative unit), where they act as processors mediating computations that convey information from diverse volume-transmitted signals. For instance, the adenosine A2A-dopamine D2 receptor heteromers work as integrators of two different neurotransmitters in the striatal spine module.
2007
7
2
74
85
Adenosine Receptor Heteromers and their Integrative Role in Striatal Function / S., Ferré; F., Ciruela; C., Quiroz; R., Luján; P., Popoli; R. A., Cunha; Agnati, Luigi Francesco; K., Fuxe; A. S., Woods; C., Lluis; R., Franco. - In: THE SCIENTIFIC WORLD JOURNAL. - ISSN 1537-744X. - STAMPA. - 7:2(2007), pp. 74-85. [10.1100/tsw.2007.211]
S., Ferré; F., Ciruela; C., Quiroz; R., Luján; P., Popoli; R. A., Cunha; Agnati, Luigi Francesco; K., Fuxe; A. S., Woods; C., Lluis; R., Franco...espandi
File in questo prodotto:
File Dimensione Formato  
829039.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 1.25 MB
Formato Adobe PDF
1.25 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/593427
Citazioni
  • ???jsp.display-item.citation.pmc??? 38
  • Scopus 85
  • ???jsp.display-item.citation.isi??? ND
social impact