Common architecture of cytokine receptors and G-protein coupled receptors (GPCRs) may underlie pathological receptor heteromer formation and signaling. Here, we clarify how chemokines and cytokines can participate in pathogenic processes of Parkinson's disease, especially in dopaminergic neurons of substantia nigra. Possible common architecture of GPCRs and cytokine receptors suggests that they may act as molecular switches similar to the prototypical innate immune receptors: Toll-like receptors. Thus, pathological signaling (as well as trafficking and internalization) of receptors may be initiated by their incorrect dimerization depending on direct or indirect (via adaptor proteins) receptor–receptor interactions, leading to neuroinflammatory responses.

A new road to neuroinflammation in Parkinson's disease? / K., Fuxe; A., Tarakanovb; L. B., Goncharovac; Agnati, Luigi Francesco. - In: BRAIN RESEARCH REVIEWS. - ISSN 0165-0173. - STAMPA. - 58:2(2008), pp. 453-458. [10.1016/j.brainresrev.2008.04.003]

A new road to neuroinflammation in Parkinson's disease?

AGNATI, Luigi Francesco
2008

Abstract

Common architecture of cytokine receptors and G-protein coupled receptors (GPCRs) may underlie pathological receptor heteromer formation and signaling. Here, we clarify how chemokines and cytokines can participate in pathogenic processes of Parkinson's disease, especially in dopaminergic neurons of substantia nigra. Possible common architecture of GPCRs and cytokine receptors suggests that they may act as molecular switches similar to the prototypical innate immune receptors: Toll-like receptors. Thus, pathological signaling (as well as trafficking and internalization) of receptors may be initiated by their incorrect dimerization depending on direct or indirect (via adaptor proteins) receptor–receptor interactions, leading to neuroinflammatory responses.
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A new road to neuroinflammation in Parkinson's disease? / K., Fuxe; A., Tarakanovb; L. B., Goncharovac; Agnati, Luigi Francesco. - In: BRAIN RESEARCH REVIEWS. - ISSN 0165-0173. - STAMPA. - 58:2(2008), pp. 453-458. [10.1016/j.brainresrev.2008.04.003]
K., Fuxe; A., Tarakanovb; L. B., Goncharovac; Agnati, Luigi Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/593335
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