A group of 31 oncohaemopathic patients (17 male, mean age 44 +/- 6 years), diagnosed as having primary deep fungal infection involving the lungs, were retrospectively evaluated. When infection was suspected on a clinical basis the major associated risks for death were the duration of bone marrow aplasia (12 +/- 7 versus 21 +/- 6 days, P < 0.001), increase in white blood cells and, in particular, prolonged granulocytopenia (11 +/- 5 versus 24 +/- 8 days, P < 0.001) when survivors were compared with patients, who died. Our therapeutic empirical approach was based on the association of i.v. amphotericin B, 1 mg kg-1 day-1, with oral 5-fluorocytosine (5-FC) 150 mg kg-1 day-1. Only 9 subjects received combination therapy for more than 7 days. For majority of them, oral 5-FC was interrupted because of altered compliance or sustained liver damage. A chi 2 test for independent parameters showed (P = 0.0021) a concentration of deaths among patients who received amphotericin B alone (15/22); none of the patients treated with amphotericin B + 5-FC (9 cases) died. Results generally suggest that a more favourable outcome was statistically associated with empirical antifungal combination therapy in deep fungal infection, although both treatment regimens showed effectiveness in terms of survival. Nevertheless the low 5-FC compliance and the small sample do not indicate the safe use of this drug in a large population.
Association therapy as a prognostic factor in deep fungal infection complicating oncohaematological diseases / E., Pogliani; Clini, Enrico. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 2(1994), pp. 385-388.
|Data di pubblicazione:||1994|
|Titolo:||Association therapy as a prognostic factor in deep fungal infection complicating oncohaematological diseases.|
|Autore/i:||E., Pogliani; Clini, Enrico|
|Codice identificativo ISI:||WOS:A1994PT54000009|
|Codice identificativo Scopus:||2-s2.0-0028541436|
|Codice identificativo Pubmed:||7858932|
|Citazione:||Association therapy as a prognostic factor in deep fungal infection complicating oncohaematological diseases / E., Pogliani; Clini, Enrico. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 2(1994), pp. 385-388.|
|Tipologia||Articolo su rivista|
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