Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminster-fullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report me provide the first demonstration that a water-soluble fullerene derivative, C-3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in Epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. (C) 1999 Federation of European Biochemical Societies.

C-3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability / E., Straface; B., Natalini; D., Monti; C., Franceschi; G., Schettini; M., Bisaglia; C., Fumelli; Pincelli, Carlo; R., Pellicciari; W., Malorni. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 454(1999), pp. 335-340.

C-3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability

PINCELLI, Carlo;
1999

Abstract

Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminster-fullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report me provide the first demonstration that a water-soluble fullerene derivative, C-3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in Epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. (C) 1999 Federation of European Biochemical Societies.
454
335
340
C-3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability / E., Straface; B., Natalini; D., Monti; C., Franceschi; G., Schettini; M., Bisaglia; C., Fumelli; Pincelli, Carlo; R., Pellicciari; W., Malorni. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 454(1999), pp. 335-340.
E., Straface; B., Natalini; D., Monti; C., Franceschi; G., Schettini; M., Bisaglia; C., Fumelli; Pincelli, Carlo; R., Pellicciari; W., Malorni
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/592629
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