This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression; thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.
Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog / S., Bencini; Migaldi, Mario; G., Castagnetti; Pincelli, Carlo; P., Ferrari; DE GAETANI, Carmela; G. P., Trentini. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - STAMPA. - 1010:(2003), pp. 789-792. [10.1196/annals.1299.142]
Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog
MIGALDI, Mario;PINCELLI, Carlo;DE GAETANI, Carmela;
2003
Abstract
This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression; thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.
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