A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000) / J. D., W., S., S., K. E., A., F. M., B., D. P., B., M., B., J. M., G., T. L., D., G., D., P. J., F., A., G., J. M., L., A., L., T., M., Seidenari, S., A., T., J. E., W.. - In: CONTACT DERMATITIS. - ISSN 0105-1873. - STAMPA. - 46:4(2002), pp. 207-210. [10.1034/j.1600-0536.2002.460404.x]
Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)
SEIDENARI, Stefania;
2002
Abstract
A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
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