Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.
Routine patch testing with frullanolide mix: An European Environmental and Contact Dermatitis Research Group multicentre study / G., Ducombs; J. P., Lepoittevin; V., Berl; K. E., Andersen; F. M., Brandao; D. P., Bruynzeel; M., Bruze; J. G., Camarasa; P. J., Frosch; A., Goossens; J. M., Lachapelle; A., Lahti; C. J., Le; H. I., Maibach; T., Menne; Seidenari, Stefania; S., Shaw; A., Tosti; J. D., Wilkinson. - In: CONTACT DERMATITIS. - ISSN 0105-1873. - STAMPA. - 48:3(2003), pp. 158-161. [10.1034/j.1600-0536.2003.00077.x]
Routine patch testing with frullanolide mix: An European Environmental and Contact Dermatitis Research Group multicentre study
SEIDENARI, Stefania;
2003
Abstract
Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.
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