Using direct electrochemistry techniques, we tackled the problem of how and to what extent intrinsic molecularfactors and medium conditions such as the pH, ionic strength, specific anion binding, the presence of non aqueoussolvents and the temperature control the reduction potential (E °') of the metal center in ET metalloproteins. Thedistinctive feature of our approach was to focus on the enthalpy and entropy changes accompanying protein reduction.These parameters revealed to be informative on the role of first coordination sphere effects, electrostatics at the metalproteininterface, solvent reorganization effects, oxidation state dependent differences in protein dynamics andenthalpy/entropy compensation phenomena as E °' effectors in cytochromes c, Fe-S proteins and blue copper proteins.

Redox Thermodynamics of electron transport metalloproteins / Sola, Marco; Battistuzzi, Gianantonio; Borsari, Marco. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - STAMPA. - 86:1(2001), pp. 514-514. (Intervento presentato al convegno ICBIC 10-10th International Conference on Bioinorganic Chemistry tenutosi a Florence nel 26-31 August 2001).

Redox Thermodynamics of electron transport metalloproteins

SOLA, Marco;BATTISTUZZI, Gianantonio;BORSARI, Marco
2001

Abstract

Using direct electrochemistry techniques, we tackled the problem of how and to what extent intrinsic molecularfactors and medium conditions such as the pH, ionic strength, specific anion binding, the presence of non aqueoussolvents and the temperature control the reduction potential (E °') of the metal center in ET metalloproteins. Thedistinctive feature of our approach was to focus on the enthalpy and entropy changes accompanying protein reduction.These parameters revealed to be informative on the role of first coordination sphere effects, electrostatics at the metalproteininterface, solvent reorganization effects, oxidation state dependent differences in protein dynamics andenthalpy/entropy compensation phenomena as E °' effectors in cytochromes c, Fe-S proteins and blue copper proteins.
2001
86
514
514
Sola, Marco; Battistuzzi, Gianantonio; Borsari, Marco
Redox Thermodynamics of electron transport metalloproteins / Sola, Marco; Battistuzzi, Gianantonio; Borsari, Marco. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - STAMPA. - 86:1(2001), pp. 514-514. (Intervento presentato al convegno ICBIC 10-10th International Conference on Bioinorganic Chemistry tenutosi a Florence nel 26-31 August 2001).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/592094
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