Background The aim of this clinical trial was to assess the efficacy and safety of calcipotriol cream associated with oraletretinate compared with etretinate alone in the treatment of moderate-severe psoriasis.Methods This controlled multicenter trial, within patients (hemiparts), enrolled 86 in- or out-patients (62 males, 24 females),mean (LSD) age 57.1 5 14.2 years, with psoriasis vulgaris on both sides of the body, and mean (LSE) baseline PASI score(Psoriasis Area and Severity Index) 30.7 ? 0.9. All patients took oral etretinate 50 mg/day and applied calcipotriol cream (50kg/g) on one half of their body twice a day. Treatment was continued for 9 weeks, and patients were seen every 3 weeks.Results At the end of the first 3 weeks the PASI score indicated a significant clinical difference between the two sides of thebody (P < 0,001, ANOVA), with a reduction of 50.7% in the score for the calcipotriol-treated half, compared with a 39%reduction for the untreated half. By the 9th week of treatment the PASI score was 81.4% lower on the treated half, and 70.3% onthe untreated side (P < 0.001, ANOVA).Conclusions These findings suggest that patients with moderate-severe psoriasis might benefit from treatment with etretinateplus calcipotriol, with the aim of achieving a faster response and an overall smaller total dose of etretinate.
Clinical trial of the efficacy and safety of oral etretinate withcalcipotriol cream compared with etretinate alone inmoderate-severe psoriasis / Giannetti, Alberto; Coppini, Maurizio; M. G., Bertazzoni; A., Califano; E., Altieri; A., Pazzaglia; M., Lega; M., Lombardo; C., Pelfini; C. V., Fornasa; G., Rabbiosi; M., Cespa. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - STAMPA. - 13(1999), pp. 91-95.
Data di pubblicazione: | 1999 | |
Titolo: | Clinical trial of the efficacy and safety of oral etretinate withcalcipotriol cream compared with etretinate alone inmoderate-severe psoriasis | |
Autore/i: | Giannetti, Alberto; Coppini, Maurizio; M. G., Bertazzoni; A., Califano; E., Altieri; A., Pazzaglia; M., Lega; M., Lombardo; C., Pelfini; C. V., Fornasa; G., Rabbiosi; M., Cespa | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 13 | |
Pagina iniziale: | 91 | |
Pagina finale: | 95 | |
Codice identificativo ISI: | WOS:000083770700002 | |
Codice identificativo Scopus: | 2-s2.0-6544294741 | |
Codice identificativo Pubmed: | 10568486 | |
Citazione: | Clinical trial of the efficacy and safety of oral etretinate withcalcipotriol cream compared with etretinate alone inmoderate-severe psoriasis / Giannetti, Alberto; Coppini, Maurizio; M. G., Bertazzoni; A., Califano; E., Altieri; A., Pazzaglia; M., Lega; M., Lombardo; C., Pelfini; C. V., Fornasa; G., Rabbiosi; M., Cespa. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - STAMPA. - 13(1999), pp. 91-95. | |
Tipologia | Articolo su rivista |
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