OBJECTIVE: To evaluate the characteristics of EEG paroxysms and the relationship between EEG spikes and ictal myoclonic jerks in patients with juvenile myoclonic epilepsy (JME). METHODS: Six patients with a typical form of JME entered the study and underwent computerized polygraphic recordings. In each patient, the inter-peak spike interval was measured on repeated EEG bursts, and jerk-locked back averaging was performed on ictal epochs using a time window including the 100 ms before and the 100-200 ms after the point at which the jerk-related EMG potential diverged from baseline. RESULTS: In all cases, the myoclonic jerks were associated with polyspike waves (PSW) complexes. The frequency of repeated spikes within the PSW complex ranged from 16 to 27 Hz. Jerk-locked averaging revealed a positive-negative EEG transient with maximal amplitude on the frontal leads, which preceded the myoclonic jerk by 10.25+/-0.96 ms. A delay of 9.50+/-1.73 ms was measured between the jerk-locked positive peak detected on the frontal EEG leads of the two hemispheres; a comparable time lag was observed between the onset of myoclonic jerks in the two deltoid muscles. CONCLUSIONS: Our data suggest that the ultimate mechanism responsible for ictal myoclonic jerks in JME is largely similar to that sustaining cortical myoclonus in more severe pathological conditions such as progressive myoclonus epilepsies, despite the different pathogenic substrate and triggering mechanisms.

Cortical myoclonus in Janz syndrome / F., Panzica; G., Rubboli; S., Franceschetti; G., Avanzini; Meletti, Stefano; A., Pozzi; C. A., Tassinari. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - STAMPA. - 112:10(2001), pp. 1803-1809. [10.1016/S1388-2457(01)00634-4]

Cortical myoclonus in Janz syndrome

MELETTI, Stefano;
2001

Abstract

OBJECTIVE: To evaluate the characteristics of EEG paroxysms and the relationship between EEG spikes and ictal myoclonic jerks in patients with juvenile myoclonic epilepsy (JME). METHODS: Six patients with a typical form of JME entered the study and underwent computerized polygraphic recordings. In each patient, the inter-peak spike interval was measured on repeated EEG bursts, and jerk-locked back averaging was performed on ictal epochs using a time window including the 100 ms before and the 100-200 ms after the point at which the jerk-related EMG potential diverged from baseline. RESULTS: In all cases, the myoclonic jerks were associated with polyspike waves (PSW) complexes. The frequency of repeated spikes within the PSW complex ranged from 16 to 27 Hz. Jerk-locked averaging revealed a positive-negative EEG transient with maximal amplitude on the frontal leads, which preceded the myoclonic jerk by 10.25+/-0.96 ms. A delay of 9.50+/-1.73 ms was measured between the jerk-locked positive peak detected on the frontal EEG leads of the two hemispheres; a comparable time lag was observed between the onset of myoclonic jerks in the two deltoid muscles. CONCLUSIONS: Our data suggest that the ultimate mechanism responsible for ictal myoclonic jerks in JME is largely similar to that sustaining cortical myoclonus in more severe pathological conditions such as progressive myoclonus epilepsies, despite the different pathogenic substrate and triggering mechanisms.
2001
112
10
1803
1809
Cortical myoclonus in Janz syndrome / F., Panzica; G., Rubboli; S., Franceschetti; G., Avanzini; Meletti, Stefano; A., Pozzi; C. A., Tassinari. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - STAMPA. - 112:10(2001), pp. 1803-1809. [10.1016/S1388-2457(01)00634-4]
F., Panzica; G., Rubboli; S., Franceschetti; G., Avanzini; Meletti, Stefano; A., Pozzi; C. A., Tassinari
File in questo prodotto:
File Dimensione Formato  
2001_CLINNEUROPHYSIOL.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 908.42 kB
Formato Adobe PDF
908.42 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/590757
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 45
  • ???jsp.display-item.citation.isi??? 37
social impact