Random Boolean networks (RBN) have been extensively studied asmodels of genetic regulatory networks. While many studies have been devoted tothe dynamics of isolated random Boolean networks, which may considered asmodels of isolated cells, in this paper we consider a set of interacting RBNs,which may be regarded as a simplified model of a tissue or a monoclonal colony.In order to do so, we introduce a cellular automata (CA) model, where each cellsite is occupied by a RBN. The mutual influence among cells is modelled byletting the activation of some genes in a RBN be affected by that of some genes inneighbouring RBNs. It is shown that the dynamics of the CA is far from trivial.Different measures are introduced to provide indications about the overallbehaviour. In a sense which is made precise in the text, it is shown that the degreeof order of the CA is affected by the interaction strength, and that markedlydifferent behaviours are observed. We propose a classification of these behavioursinto four classes, based upon the way in which the various measures of order areaffected by the interaction strength. It is shown that the dynamical properties ofisolated RBNs affect the probability that a CA composed by those RBNs belongsto one of the four classes, and therefore also affects the probability that a higherinteraction strength leads to a greater, or a smaller, degree of order.
|Data di pubblicazione:||2007|
|Titolo:||Interacting random boolean networks|
|Autori:||R. SERRA; M. VILLANI; C. DAMIANI ; A. GRAUDENZI ; A. COLACCI ; S.A. KAUFFAMN|
|Data del convegno:||ottobre 2007|
|Nome del convegno:||European Conference on Complex Systems|
|Luogo del convegno:||Dresden|
|Titolo del libro:||Proceedings of ECCS07: European Conference on Complex Systems|
|Appare nelle tipologie:||Relazione in Atti di Convegno|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris