Changes in dynamic viscosity of the solutions of a high-molar-mass hyaluronan (HA) were monitored using a rotational viscometer. The degradative conditions generated in the HA solutions by a system comprising ascorbate plus Cu(II) plus H(2)O(2) were studied either in the presence or absence of a drug--naproxen or acetylsalicylic acid. Continual decrease of the dynamic viscosity of HA solution was indicative of the polymer degradation. Addition of the drug retarded/inhibited the HA degradation in a concentration-dependent manner. The characteristics of the fragmented polymers were investigated by FT-IR spectroscopy and by two different liquid chromatographic techniques, namely by size-exclusion chromatography equipped with a multi-angle light scattering photometric detector and by high-performance liquid chromatography connected on-line to a spectrofluorometer.
Degradation of high-molar-mass hyaluronan by an oxidative system comprising ascorbate, Cu(II), and hydrogen peroxide: inhibitory action of antiinflammatory drugs - naproxen and acetylsalicylic acid / Soltes, L; Stankovska, M; Kogan, G; Mendichi, R; Volpi, Nicola; Sasinkova, V; Gemeiner, P.. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 44(2007), pp. 1056-1063.
Data di pubblicazione: | 2007 | |
Titolo: | Degradation of high-molar-mass hyaluronan by an oxidative system comprising ascorbate, Cu(II), and hydrogen peroxide: inhibitory action of antiinflammatory drugs - naproxen and acetylsalicylic acid. | |
Autore/i: | Soltes, L; Stankovska, M; Kogan, G; Mendichi, R; Volpi, Nicola; Sasinkova, V; Gemeiner, P. | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 44 | |
Pagina iniziale: | 1056 | |
Pagina finale: | 1063 | |
Codice identificativo ISI: | WOS:000249469000005 | |
Codice identificativo Scopus: | 2-s2.0-34547814615 | |
Codice identificativo Pubmed: | 17553647 | |
Citazione: | Degradation of high-molar-mass hyaluronan by an oxidative system comprising ascorbate, Cu(II), and hydrogen peroxide: inhibitory action of antiinflammatory drugs - naproxen and acetylsalicylic acid / Soltes, L; Stankovska, M; Kogan, G; Mendichi, R; Volpi, Nicola; Sasinkova, V; Gemeiner, P.. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - STAMPA. - 44(2007), pp. 1056-1063. | |
Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris