Six newly synthesized triazoles were tested on the pathogen Nannizzia cajetani in order to evaluate their antifungal activity. At the doses used (10, 50 e 100 µg/ml) none of the six substances achieved MIC although they all gave a dose-dependent response. The highest degree of inhibition was achieved with 1-amino-6-methyl-4-phenylpyrazolo[3,4-d]-1,2,3-triazole at the highest dose tested. Scanning Electron Microscopy of the samples treated with this triazole showed the total disappearance of the macroconids. The data are discussed on the basis of the structure-activity relationship.

Antifungal activity of six newly synthesized triazoles / Romagnoli, Carlo; Sacchetti, G; Vicentini, C. B. AND MARES D.. - In: BIOMEDICAL LETTERS. - ISSN 0961-088X. - STAMPA. - 58:(1998), pp. 147-153.

Antifungal activity of six newly synthesized triazoles

ROMAGNOLI, Carlo;
1998

Abstract

Six newly synthesized triazoles were tested on the pathogen Nannizzia cajetani in order to evaluate their antifungal activity. At the doses used (10, 50 e 100 µg/ml) none of the six substances achieved MIC although they all gave a dose-dependent response. The highest degree of inhibition was achieved with 1-amino-6-methyl-4-phenylpyrazolo[3,4-d]-1,2,3-triazole at the highest dose tested. Scanning Electron Microscopy of the samples treated with this triazole showed the total disappearance of the macroconids. The data are discussed on the basis of the structure-activity relationship.
58
147
153
Antifungal activity of six newly synthesized triazoles / Romagnoli, Carlo; Sacchetti, G; Vicentini, C. B. AND MARES D.. - In: BIOMEDICAL LETTERS. - ISSN 0961-088X. - STAMPA. - 58:(1998), pp. 147-153.
Romagnoli, Carlo; Sacchetti, G; Vicentini, C. B. AND MARES D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/585544
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