Deux activités antifongiques du 3-méthyl-5-aminoisoxazole-4-thiocyanate ont été étudiées chez les espèces de levures : Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, et Rhodotorula glutinis. Une inhibition significative de la croissance de chacune des levures a été évidente. Des modifications ultrastructurales ont révélé que le composé, à demi-dose de la concentration inhibitrice minimale (MIC) (1,25 μg.mL-1), causait une transformation de la levure vers la forme mycéllale par formation d'un tube germinal chez le R. glutinis. L'accumulation de quantités anormales de substances pariétales après traitement avec la MIC est discutée en relation avec la production de chitine et d'ergostérol.Two antifungal activities of 3-methyl-5-aminoisoxazole-4-thiocyanate have been studied in yeast species: Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Rhodotorula glutinis. A significant inhibition of growth of each yeast was evident. Ultrastructural changes showed that the compound, half-dose of the minimum inhibitory concentration (MIC) (1.25 μg.mL-1), causing a transformation of the yeast to form mycéllale by formation of a germ tube at the R. glutinis. The accumulation of abnormal amounts of substances parietal after treatment with the MIC is discussed in relation to the production of chitin and ergosterol.

Antifungal properties of the 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts. An Unusual dose-dependent effect on Rhodotorula glutinis Harrison / D., Mares; Romagnoli, Carlo; A., Donini; A., Bruni. - In: CANADIAN JOURNAL OF MICROBIOLOGY. - ISSN 0008-4166. - STAMPA. - 42:(1996), pp. 191-195.

Antifungal properties of the 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts. An Unusual dose-dependent effect on Rhodotorula glutinis Harrison

ROMAGNOLI, Carlo;
1996

Abstract

Deux activités antifongiques du 3-méthyl-5-aminoisoxazole-4-thiocyanate ont été étudiées chez les espèces de levures : Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, et Rhodotorula glutinis. Une inhibition significative de la croissance de chacune des levures a été évidente. Des modifications ultrastructurales ont révélé que le composé, à demi-dose de la concentration inhibitrice minimale (MIC) (1,25 μg.mL-1), causait une transformation de la levure vers la forme mycéllale par formation d'un tube germinal chez le R. glutinis. L'accumulation de quantités anormales de substances pariétales après traitement avec la MIC est discutée en relation avec la production de chitine et d'ergostérol.Two antifungal activities of 3-methyl-5-aminoisoxazole-4-thiocyanate have been studied in yeast species: Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Rhodotorula glutinis. A significant inhibition of growth of each yeast was evident. Ultrastructural changes showed that the compound, half-dose of the minimum inhibitory concentration (MIC) (1.25 μg.mL-1), causing a transformation of the yeast to form mycéllale by formation of a germ tube at the R. glutinis. The accumulation of abnormal amounts of substances parietal after treatment with the MIC is discussed in relation to the production of chitin and ergosterol.
42
191
195
Antifungal properties of the 3-methyl-5-aminoisoxazole-4-thiocyanate on four yeasts. An Unusual dose-dependent effect on Rhodotorula glutinis Harrison / D., Mares; Romagnoli, Carlo; A., Donini; A., Bruni. - In: CANADIAN JOURNAL OF MICROBIOLOGY. - ISSN 0008-4166. - STAMPA. - 42:(1996), pp. 191-195.
D., Mares; Romagnoli, Carlo; A., Donini; A., Bruni
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/585536
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact