An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.
A mild synthesis of nitriles by TPPX2-promoted dehydration of primary amides / Vaccari, Daniele; Davoli, Paolo; Spaggiari, Alberto; Bucciarelli, Maria; Prati, Fabio. - In: LETTERS IN ORGANIC CHEMISTRY. - ISSN 1570-1786. - STAMPA. - 4:5(2007), pp. 319-321. [10.2174/157017807781212157]
A mild synthesis of nitriles by TPPX2-promoted dehydration of primary amides
VACCARI, Daniele;DAVOLI, Paolo;SPAGGIARI, Alberto;BUCCIARELLI, Maria;PRATI, Fabio
2007
Abstract
An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.
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