Cultured human keratinocytes have a wide spectrum of clinical applications. Clinical results reported by several investigators are, however, contradictory. In this review, the authors discuss the biological and surgical issues which play a key role in the clinical outcome of cultured epidermal autografts used for the treatment of massive full-thickness burns. The importance of cultivation of epidermal stem cells and of their transplantation onto a wound bed prepared with donor dermis is emphasised. The paper also reviews recent data showing that: (i) cultured epidermal autografts bearing melanocytes can be used for the treatment of stable vitiligo; (ii) keratinocytes isolated from other lining epithelia, such as oral, urethral and corneal epithelia, can be cultivated and grafted onto patients suffering from disabling epithelial defects; (iii) keratinocyte stem cells can be stably transduced with retroviral vectors and are therefore attractive targets for the gene therapy of genodermatoses.
Cultivation of human keratinocyte stem cells: current and future clinical applications / Pellegrini, Graziella; Bondanza, S; Guerra, L.; DE LUCA, Michele. - In: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. - ISSN 0140-0118. - STAMPA. - 36(1998), pp. 778-790.
Data di pubblicazione: | 1998 |
Titolo: | Cultivation of human keratinocyte stem cells: current and future clinical applications |
Autore/i: | Pellegrini, Graziella; Bondanza, S; Guerra, L.; DE LUCA, Michele |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 36 |
Pagina iniziale: | 778 |
Pagina finale: | 790 |
Codice identificativo ISI: | WOS:000077431600020 |
Codice identificativo Scopus: | 2-s2.0-0032213367 |
Codice identificativo Pubmed: | 10367472 |
Citazione: | Cultivation of human keratinocyte stem cells: current and future clinical applications / Pellegrini, Graziella; Bondanza, S; Guerra, L.; DE LUCA, Michele. - In: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING. - ISSN 0140-0118. - STAMPA. - 36(1998), pp. 778-790. |
Tipologia | Articolo su rivista |
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