An 18-month-old girl was diagnosed with prepre-B ALL/t(4;11) leukemia, which during thetreatment and after matched bone marrow transplantation(BMT), underwent two consecutiveswitches from lymphoid to myeloid lineage andvice versa. The high expression of HOXA9 andFLT3 genes remaining genotypically stable in aleukemia throughout phenotypic switches, suggeststhat this leukemia may have originated as acommon B/myeloid progenitors.
Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia / G., Germano; M., Pigazzi; L., Del Giudice; M., Campo Dellorto; M., Spinelli; A., Zangrando; Paolucci, Paolo; S., Ladogana; G., Basso. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 91:5(2006), pp. 29-31.
Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia
PAOLUCCI, Paolo;
2006
Abstract
An 18-month-old girl was diagnosed with prepre-B ALL/t(4;11) leukemia, which during thetreatment and after matched bone marrow transplantation(BMT), underwent two consecutiveswitches from lymphoid to myeloid lineage andvice versa. The high expression of HOXA9 andFLT3 genes remaining genotypically stable in aleukemia throughout phenotypic switches, suggeststhat this leukemia may have originated as acommon B/myeloid progenitors.
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