In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.

The alpha1a and alpha1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action / S., Cotecchia; O., Rossier; Fanelli, Francesca; A., Leonardi; PIER G., DE BENEDETTI. - In: PHARMACEUTICA ACTA HELVETIAE. - ISSN 0031-6865. - ELETTRONICO. - 74:(2000), pp. 173-179. [10.1016/S0031-6865(99)00031-X]

The alpha1a and alpha1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action

FANELLI, Francesca;
2000

Abstract

In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
74
173
179
The alpha1a and alpha1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action / S., Cotecchia; O., Rossier; Fanelli, Francesca; A., Leonardi; PIER G., DE BENEDETTI. - In: PHARMACEUTICA ACTA HELVETIAE. - ISSN 0031-6865. - ELETTRONICO. - 74:(2000), pp. 173-179. [10.1016/S0031-6865(99)00031-X]
S., Cotecchia; O., Rossier; Fanelli, Francesca; A., Leonardi; PIER G., DE BENEDETTI
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/584276
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 10
  • ???jsp.display-item.citation.isi??? ND
social impact