In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
The alpha1a and alpha1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action / S., Cotecchia; O., Rossier; Fanelli, Francesca; A., Leonardi; PIER G., DE BENEDETTI. - In: PHARMACEUTICA ACTA HELVETIAE. - ISSN 0031-6865. - ELETTRONICO. - 74:2-3(2000), pp. 173-179. [10.1016/S0031-6865(99)00031-X]
The alpha1a and alpha1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action
FANELLI, Francesca;
2000
Abstract
In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
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