The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.

The alpha(1b)-adrenergic receptor subtype: Molecular properties and physiological implications / S., Cotecchia; K., Bjrklf; O., Rossier; L., Stanasila; P., Greasley; Fanelli, Francesca. - In: JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. - ISSN 1079-9893. - ELETTRONICO. - 22(2002), pp. 1-16. [10.1081/RRS.120014585]

The alpha(1b)-adrenergic receptor subtype: Molecular properties and physiological implications

FANELLI, Francesca
2002

Abstract

The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.
22
1
16
The alpha(1b)-adrenergic receptor subtype: Molecular properties and physiological implications / S., Cotecchia; K., Bjrklf; O., Rossier; L., Stanasila; P., Greasley; Fanelli, Francesca. - In: JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. - ISSN 1079-9893. - ELETTRONICO. - 22(2002), pp. 1-16. [10.1081/RRS.120014585]
S., Cotecchia; K., Bjrklf; O., Rossier; L., Stanasila; P., Greasley; Fanelli, Francesca
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/584274
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact