The luteinizing hormone receptor (LHR) is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimeric glycoprotein hormone family. This receptor is an essential component of the reproductive axis in males and females, and a number of naturally occurring pathophysiologic activating and inactivating mutations have been described. This review deals with the current state of knowledge of the structure of LHR based on molecular modeling and the supporting experimental data from engineered and naturally occurring mutations.
Structural Aspects of the Luteinizing Hormone Receptor: Information from Molecular Modeling and Mutagenesis / Fanelli, Francesca; D., Puett. - In: ENDOCRINE. - ISSN 1355-008X. - ELETTRONICO. - 18:3(2002), pp. 285-293. [10.1385/ENDO:18:3:285]
Structural Aspects of the Luteinizing Hormone Receptor: Information from Molecular Modeling and Mutagenesis
FANELLI, Francesca;
2002
Abstract
The luteinizing hormone receptor (LHR) is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimeric glycoprotein hormone family. This receptor is an essential component of the reproductive axis in males and females, and a number of naturally occurring pathophysiologic activating and inactivating mutations have been described. This review deals with the current state of knowledge of the structure of LHR based on molecular modeling and the supporting experimental data from engineered and naturally occurring mutations.
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