OBJECTIVE: The purpose of this study was to evaluate whether 17-alpha-hydroxyprogesterone caproate (17P) treatment affect changes in cervical length. STUDY DESIGN: Women with singleton pregnancy, between 25 and 33 + 6 weeks of gestation, who were hospitalized for preterm labor were included. Patients with rupture of membranes and/or signs of chorioamnionitis were excluded. Sixty undelivered patients were allocated randomly to either observation or to receive 341 mg of 17P intramuscularly, twice each week until gestational week 36. Cervical length was measured by transvaginal ultrasound scanning at discharge and at day 7 and 21 after discharge. Statistical comparisons were done with analysis of variance and chi-square test. RESULTS: Shortening of the cervix in the observation group (30 cases) was higher than in the 17P group (30 cases) both at day 7 (2.37 +/- 2.0 mm vs 0.83 +/- 1.74 mm; P = .002) and day 21 (4.60 +/- 2.73 mm vs 2.40 +/- 2.46 mm; P = .002). Treatment with 17P was associated with both a reduction in the risk of cervical shortening of > or = 4 mm (odds ratio, 0.18; 95% CI, 0.04-0.66) and in the risk of preterm delivery (odds ratio, 0.15; 95% CI, 0.04-0.58). CONCLUSION: Undelivered patients after preterm labor undergo progressive shortening of the cervix, which is attenuated by 17P treatment

Cervical length changes during preterm cervical ripening: effects of 17-alfa hydroxy progesterone caproate / Facchinetti, Fabio; Paganelli, S; Comitini, G; Dante, G; Volpe, Annibale. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - STAMPA. - 196:(2007), pp. 453.e1-453.e4.

Cervical length changes during preterm cervical ripening: effects of 17-alfa hydroxy progesterone caproate

FACCHINETTI, Fabio;VOLPE, Annibale
2007

Abstract

OBJECTIVE: The purpose of this study was to evaluate whether 17-alpha-hydroxyprogesterone caproate (17P) treatment affect changes in cervical length. STUDY DESIGN: Women with singleton pregnancy, between 25 and 33 + 6 weeks of gestation, who were hospitalized for preterm labor were included. Patients with rupture of membranes and/or signs of chorioamnionitis were excluded. Sixty undelivered patients were allocated randomly to either observation or to receive 341 mg of 17P intramuscularly, twice each week until gestational week 36. Cervical length was measured by transvaginal ultrasound scanning at discharge and at day 7 and 21 after discharge. Statistical comparisons were done with analysis of variance and chi-square test. RESULTS: Shortening of the cervix in the observation group (30 cases) was higher than in the 17P group (30 cases) both at day 7 (2.37 +/- 2.0 mm vs 0.83 +/- 1.74 mm; P = .002) and day 21 (4.60 +/- 2.73 mm vs 2.40 +/- 2.46 mm; P = .002). Treatment with 17P was associated with both a reduction in the risk of cervical shortening of > or = 4 mm (odds ratio, 0.18; 95% CI, 0.04-0.66) and in the risk of preterm delivery (odds ratio, 0.15; 95% CI, 0.04-0.58). CONCLUSION: Undelivered patients after preterm labor undergo progressive shortening of the cervix, which is attenuated by 17P treatment
196
453.e1
453.e4
Cervical length changes during preterm cervical ripening: effects of 17-alfa hydroxy progesterone caproate / Facchinetti, Fabio; Paganelli, S; Comitini, G; Dante, G; Volpe, Annibale. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - STAMPA. - 196:(2007), pp. 453.e1-453.e4.
Facchinetti, Fabio; Paganelli, S; Comitini, G; Dante, G; Volpe, Annibale
File in questo prodotto:
File Dimensione Formato  
am j obst gyn17P.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 134 kB
Formato Adobe PDF
134 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/584200
Citazioni
  • ???jsp.display-item.citation.pmc??? 35
  • Scopus 117
  • ???jsp.display-item.citation.isi??? 68
social impact