RATIONALE: Acidification of the airways seems to be involved in asthma pathophysiology, but its assessment might be difficult. OBJECTIVES: The aim of our study is to assess the feasibility and validity of airway acidification measurement by induced sputum and its clinical significance in asthma. METHODS: Induced-sputum samples were obtained in 57 outpatients with asthma. The between-sample repeatability after 48 hours was measured in an independent population of 14 patients with asthma. pH was measured using a pH meter. The control of asthma was established by the Asthma Control Questionnaire. MEASUREMENTS AND MAIN RESULTS: The pH measurement was feasible in all samples and repeatable both within (intraclass correlation coefficient [ICC], 0.96) and between samples (ICC, 0.621). The mean pH was significantly different between healthy subjects and patients with asthma, including in those with controlled (mean pH: 7.54 in healthy subjects vs. 7.28 in subjects with controlled asthma; p = 0.0105) and uncontrolled disease (mean pH: 7.54 in healthy subjects vs. 7.06 in subjects with uncontrolled disease; p < 0.0001), and between patients with stable asthma and those with poorly controlled asthma (7.28 vs. 7.06, respectively; p = 0.0134). The validity of the method was assessed with the receiver operating characteristic curves and induced-sputum lower pH values (with a cutoff value of 7.3; sensitivity, 72.1%; specificity, 100%). CONCLUSIONS: Patients with asthma show lower pH than healthy subjects. Patients with poorly controlled asthma seem to have the lowest induced-sputum pH, independent of the GINA (Global Initiative for Asthma) severity level. In conclusion, induced sputum is a feasible, repeatable, noninvasive method to measure airway pH. The pH in induced sputum may reflect a different aspect of asthma from sputum eosinophils and be related to different pathophysiologic factors.
An investigation of airway acidification in asthma using induced sputum: a study of feasibility and correlation / M., Kodric; A. N., Shah; Fabbri, Leonardo; M., Confalonieri. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - STAMPA. - 175(2007), pp. 905-910.
Data di pubblicazione: | 2007 |
Titolo: | An investigation of airway acidification in asthma using induced sputum: a study of feasibility and correlation. |
Autore/i: | M., Kodric; A. N., Shah; Fabbri, Leonardo; M., Confalonieri |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 175 |
Pagina iniziale: | 905 |
Pagina finale: | 910 |
Codice identificativo ISI: | WOS:000246229500008 |
Codice identificativo Scopus: | 2-s2.0-34247589697 |
Codice identificativo Pubmed: | 17290044 |
Citazione: | An investigation of airway acidification in asthma using induced sputum: a study of feasibility and correlation / M., Kodric; A. N., Shah; Fabbri, Leonardo; M., Confalonieri. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - STAMPA. - 175(2007), pp. 905-910. |
Tipologia | Articolo su rivista |
File in questo prodotto:

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris