Defects of the mitochondrial genome cause a heterogeneous group of clinical disorders, including mitochondrial cardiomyopathies (MIC). The molecular events linking mtDNA defects to cardiac remodeling are unknown. Energy derangements and increase of mitochondrial-derived reactive oxygen species (ROS) could both play a role in the development of cardiac dysfunction in MIC. In addition, mitochondrial proliferation could interfere with sarcomere alignment and contraction

Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies / M, Sebastiani; C, Giordano; C, Nediani; C, Travaglini; E, Borchi; M, Zani; M, Feccia; M, Mancini; V, Petrozza; Cossarizza, A.; P, Gallo; W, Taylor R.; G, Damati. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - STAMPA. - 50 (14)(2007), pp. 1362-1369.

Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies.

A. COSSARIZZA;
2007

Abstract

Defects of the mitochondrial genome cause a heterogeneous group of clinical disorders, including mitochondrial cardiomyopathies (MIC). The molecular events linking mtDNA defects to cardiac remodeling are unknown. Energy derangements and increase of mitochondrial-derived reactive oxygen species (ROS) could both play a role in the development of cardiac dysfunction in MIC. In addition, mitochondrial proliferation could interfere with sarcomere alignment and contraction
50 (14)
1362
1369
Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies / M, Sebastiani; C, Giordano; C, Nediani; C, Travaglini; E, Borchi; M, Zani; M, Feccia; M, Mancini; V, Petrozza; Cossarizza, A.; P, Gallo; W, Taylor R.; G, Damati. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - STAMPA. - 50 (14)(2007), pp. 1362-1369.
M, Sebastiani; C, Giordano; C, Nediani; C, Travaglini; E, Borchi; M, Zani; M, Feccia; M, Mancini; V, Petrozza; Cossarizza, A.; P, Gallo; W, Taylor R.; G, Damati
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/583992
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