Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)–B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.

A whole-genome association study of major determinants for host control of HIV-1 / Fellay, J; Shianna K., V; Ge, D; Colombo, S; Ledergerber, B; Weale, M; Zhang, K; Gumbs, C; Castagna, A; Cossarizza, Andrea; Cozzi Lepri, A; De Luca, A; Easterbrook, P; Francioli, P; Mallal, S; Martinez Picado, J; Mir J., M; Obel, N; Smith J., P; Wyniger, J; Descombes, P; Antonarakis S., E; Letvin N., L; Mcmichael A., J; Haynes B., F; Telenti, A; Goldstein, D. B.. - In: SCIENCE. - ISSN 0036-8075. - STAMPA. - 317:5840(2007), pp. 944-947. [10.1126/science.1143767]

A whole-genome association study of major determinants for host control of HIV-1

COSSARIZZA, Andrea;
2007

Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)–B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
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A whole-genome association study of major determinants for host control of HIV-1 / Fellay, J; Shianna K., V; Ge, D; Colombo, S; Ledergerber, B; Weale, M; Zhang, K; Gumbs, C; Castagna, A; Cossarizza, Andrea; Cozzi Lepri, A; De Luca, A; Easterbrook, P; Francioli, P; Mallal, S; Martinez Picado, J; Mir J., M; Obel, N; Smith J., P; Wyniger, J; Descombes, P; Antonarakis S., E; Letvin N., L; Mcmichael A., J; Haynes B., F; Telenti, A; Goldstein, D. B.. - In: SCIENCE. - ISSN 0036-8075. - STAMPA. - 317:5840(2007), pp. 944-947. [10.1126/science.1143767]
Fellay, J; SHIANNA K., V; Ge, D; Colombo, S; Ledergerber, B; Weale, M; Zhang, K; Gumbs, C; Castagna, A; Cossarizza, Andrea; COZZI LEPRI, A; DE LUCA, A; Easterbrook, P; Francioli, P; Mallal, S; MARTINEZ PICADO, J; MIR J., M; Obel, N; SMITH J., P; Wyniger, J; Descombes, P; ANTONARAKIS S., E; LETVIN N., L; MCMICHAEL A., J; HAYNES B., F; Telenti, A; Goldstein, D. B.
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