A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.
Synthesis of 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors / Braghiroli, Daniela; Puja, Giulia; Cannazza, Giuseppe; Tait, A; Parenti, Carlo; Losi, G; Baraldi, M.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 45:12(2002), pp. 2355-2357. [10.1021/jm025510d]
Synthesis of 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors
BRAGHIROLI, Daniela;PUJA, Giulia;CANNAZZA, Giuseppe;PARENTI, Carlo;
2002
Abstract
A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.
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