A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.

Synthesis of 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors / Braghiroli, Daniela; Puja, Giulia; Cannazza, Giuseppe; Tait, A; Parenti, Carlo; Losi, G; Baraldi, M.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 45(2002), pp. 2355-2357. [10.1021/jm025510d]

Synthesis of 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors

BRAGHIROLI, Daniela;PUJA, Giulia;CANNAZZA, Giuseppe;PARENTI, Carlo;
2002

Abstract

A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.
45
2355
2357
Synthesis of 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors / Braghiroli, Daniela; Puja, Giulia; Cannazza, Giuseppe; Tait, A; Parenti, Carlo; Losi, G; Baraldi, M.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 45(2002), pp. 2355-2357. [10.1021/jm025510d]
Braghiroli, Daniela; Puja, Giulia; Cannazza, Giuseppe; Tait, A; Parenti, Carlo; Losi, G; Baraldi, M.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/583849
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 43
  • ???jsp.display-item.citation.isi??? 42
social impact