The trans isomer of (Z)-2-[p-(1,2-diphenyl-butenyl)phenoxy]-N,N-dimethyletylamine (tamoxifen) is well known for its endocrine activity as an antiestrogenic agent. Its citrate salt, a widely used pharmaceutical agent, appears in three main polymorphic forms, two of which are well known (I and II) and another form not yet well evidenced.A vibrational study has been conducted for identifying the two known polymorphic forms of tamoxifen citrate (I and II) and for characterising the other form (form III) examined in this study.Other techniques for the characterization of the different polymorphs, such as XRDP, have been used
Vibrational study of tamoxifen citrate polymorphism / Gamberini, Maria Cristina; Baraldi, Cecilia; A., Tinti; Palazzoli, Federica; Ferioli, Valeria. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - STAMPA. - 840:(2007), pp. 29-37. [10.1016/j.molstruc.2007.02.019]
Vibrational study of tamoxifen citrate polymorphism
GAMBERINI, Maria Cristina;BARALDI, Cecilia;PALAZZOLI, Federica;FERIOLI, Valeria
2007-01-01
Abstract
The trans isomer of (Z)-2-[p-(1,2-diphenyl-butenyl)phenoxy]-N,N-dimethyletylamine (tamoxifen) is well known for its endocrine activity as an antiestrogenic agent. Its citrate salt, a widely used pharmaceutical agent, appears in three main polymorphic forms, two of which are well known (I and II) and another form not yet well evidenced.A vibrational study has been conducted for identifying the two known polymorphic forms of tamoxifen citrate (I and II) and for characterising the other form (form III) examined in this study.Other techniques for the characterization of the different polymorphs, such as XRDP, have been used
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