The functional activity of the superior colliculus (SC) following flash stimulation was examined by means of 2-deoxyglucose (2DG) method in monocularly enucleated Long-Evans rats intraocularly injected with a solution of 2-amino-4-phosphonobutyric acid (APB), able to silence the ON retinal activity. After APB injection SC layers recipient of retinal axons suffered a sustained 2DG decrease as compared to controls. Moreover, whereas glucose utilization in normal rat SC appears unevenly distributed and closely related to retinal axon density, by contrast, APB-treated rats showed a rather uniform metabolic activity throughout the SC surface. Furthermore, we calculated the 2DG uptake percentage reduction in 12 SC loci of APB rats in respect to homologous loci of controls: glucose utilization decreases at the loci largely differ from each other, showing that retinal axons carrying ON activity are dispersed over the SC in a mosaic pattern. Thus, the SC metabolic map should be representative of its retinotopic organization which, in turn, depends on the asymmetric distribution in the rat's retina of W-like as well as of other ganglion cell types.

Intraocular injection of APB decreases the metabolic response of the rat superior colliculus / G. P., Biral; R., Ferrari; Benassi, Carlo; S., Fonda. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - STAMPA. - 31(1993), pp. 23-28.

Intraocular injection of APB decreases the metabolic response of the rat superior colliculus

BENASSI, Carlo;
1993

Abstract

The functional activity of the superior colliculus (SC) following flash stimulation was examined by means of 2-deoxyglucose (2DG) method in monocularly enucleated Long-Evans rats intraocularly injected with a solution of 2-amino-4-phosphonobutyric acid (APB), able to silence the ON retinal activity. After APB injection SC layers recipient of retinal axons suffered a sustained 2DG decrease as compared to controls. Moreover, whereas glucose utilization in normal rat SC appears unevenly distributed and closely related to retinal axon density, by contrast, APB-treated rats showed a rather uniform metabolic activity throughout the SC surface. Furthermore, we calculated the 2DG uptake percentage reduction in 12 SC loci of APB rats in respect to homologous loci of controls: glucose utilization decreases at the loci largely differ from each other, showing that retinal axons carrying ON activity are dispersed over the SC in a mosaic pattern. Thus, the SC metabolic map should be representative of its retinotopic organization which, in turn, depends on the asymmetric distribution in the rat's retina of W-like as well as of other ganglion cell types.
31
23
28
Intraocular injection of APB decreases the metabolic response of the rat superior colliculus / G. P., Biral; R., Ferrari; Benassi, Carlo; S., Fonda. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - STAMPA. - 31(1993), pp. 23-28.
G. P., Biral; R., Ferrari; Benassi, Carlo; S., Fonda
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/583533
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