EnglishIn limbic seizures, neuronal excitation is conveyed from the entorhinalcortex directly to CA1 and subicular regions. This phenomenonis associated with a reduced ability of CA3 to respond toentorhinal cortex inputs. Here, we describe a lesion that destroys theperforant path in CA3 after status epilepticus (SE) induced bypilocarpine injection in 8-week-old rats. Using magnetic resonanceimaging, immunohistochemical, and ultrastructural analyses, wedetermined that this lesion develops after 30 minutes of SE and ischaracterized by microhemorrhages and ischemia. After a longerperiod of SE, the lesion invariably involves the upper blade ofthe dentate gyrus. Adult rats treated with subcutaneous diazepam(20 mg kgj1 for 3 days) did not develop the dentate gyrus lesionand had less frequent spontaneous recurrent seizures (p G 0.01).Young (3-week-old) rats rarely (20%) developed the CA3 lesion,and their spontaneous seizures were delayed (p G 0.01). To investigatethe role of the damaged CA3 in seizure activity, wereinduced SE in adult and young epileptic rats. Using FosB/$FosBmarkers, we found induction of FosB/$FosB immunopositivity inCA3 neurons of young but not in adult rats. These experimentsindicate that SE can produce a focal lesion in the perforant path thatmay affect the roles of the hippocampus in epileptic rats.
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus / Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; Contri, Miranda; U., Guerrini; L., Sironi; P., Gelosa; Zini, Isabella; M., Avoli. - In: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. - ISSN 0022-3069. - STAMPA. - 67(2008), pp. 687-701.
| Data di pubblicazione: | 2008 | |
| Titolo: | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. | |
| Autore/i: | Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; Contri, Miranda; U., Guerrini; L., Sironi; P., Gelosa; Zini, Isabella; M., Avoli | |
| Autore/i UNIMORE: | ||
| Rivista: | ||
| Volume: | 67 | |
| Pagina iniziale: | 687 | |
| Pagina finale: | 701 | |
| Codice identificativo ISI: | WOS:000257301000006 | |
| Codice identificativo Scopus: | 2-s2.0-46249104153 | |
| Codice identificativo Pubmed: | 18596544 | |
| Citazione: | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus / Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; Contri, Miranda; U., Guerrini; L., Sironi; P., Gelosa; Zini, Isabella; M., Avoli. - In: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. - ISSN 0022-3069. - STAMPA. - 67(2008), pp. 687-701. | |
| Tipologia | Articolo su rivista |
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| Proepilectic influence Part 02.pdf | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia | |
| Proepilectic influence Part 01.pdf | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia | |
| Proepilectic influence Part 03.pdf | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia |
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