The liver presents estrogen receptors alpha and beta. As for breast cancer, a variant form of estrogen receptor alpha transcript (ER) has been described in hepatocellular carcinoma (HCC). It is derived by an exon 5-deleted transcript (vER), which lacks the hormone-binding domain of the receptor but, being intact in the DNA-binding domain, maintains constitutive transcriptional activity. HCCs presenting vER have an extremely aggressive clinical course and are unresponsive to the antiestrogen tamoxifen. On the other hand, megestrol, a drug able to block both the wild type and the variant form of ER, influence the clinical course of HCC presenting vER. The presence of vER is associated with elevated cancer cell proliferation rate. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Variant estrogen receptors and their role in liver disease / Villa, Erica; Colantoni, A; Grottola, Antonella; Ferretti, Ilva; Buttafoco, Paola; Bertani, H; De Maria, N; Manenti, Federico. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - STAMPA. - 193:1-2(2002), pp. 65-69. [10.1016/S0303-7207(02)00097-7]
Variant estrogen receptors and their role in liver disease
VILLA, Erica;GROTTOLA, Antonella;FERRETTI, Ilva;BUTTAFOCO, Paola;MANENTI, Federico
2002
Abstract
The liver presents estrogen receptors alpha and beta. As for breast cancer, a variant form of estrogen receptor alpha transcript (ER) has been described in hepatocellular carcinoma (HCC). It is derived by an exon 5-deleted transcript (vER), which lacks the hormone-binding domain of the receptor but, being intact in the DNA-binding domain, maintains constitutive transcriptional activity. HCCs presenting vER have an extremely aggressive clinical course and are unresponsive to the antiestrogen tamoxifen. On the other hand, megestrol, a drug able to block both the wild type and the variant form of ER, influence the clinical course of HCC presenting vER. The presence of vER is associated with elevated cancer cell proliferation rate. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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