We investigated the molecular relationships between lipid peroxidation and mitochondrial DNA (mtDNA) single strand breaks (ssb) in isolated rat hepatocytes and mitochondria exposed to tert-butylhydroperoxide (TBH). Our results show that mtDNA ssb induced by TBH are independent of lipid peroxidation and dependent on the presence of iron and of hydroxyl free radicals. These data contribute to the definition of the mechanisms whereby mtDNA ssb are induced and provide possible molecular targets for the prevention of this kind of damage in vivo. (C) 2003 Elsevier Science B.V. and Mitochondria Research Society. All rights reserved.
Lack of molecular relationships between lipid peroxidation and mitochondrial DNA single strand breaks in isolated rat hepatocytes and mitochondria / Scotti, C; Iamele, L; Alessandrini, Andrea; Vannini, V; Cazzalini, O; Lazze, Mc; Melli, R; Savio, M; Pizzala, R; Stivala, La; Biglieri, S; Tomasi, Aldo; Bianchi, L.. - In: MITOCHONDRION. - ISSN 1567-7249. - STAMPA. - 2:5(2003), pp. 361-373. [10.1016/S1567-7249(03)00004-7]
Lack of molecular relationships between lipid peroxidation and mitochondrial DNA single strand breaks in isolated rat hepatocytes and mitochondria
ALESSANDRINI, Andrea;TOMASI, Aldo;
2003
Abstract
We investigated the molecular relationships between lipid peroxidation and mitochondrial DNA (mtDNA) single strand breaks (ssb) in isolated rat hepatocytes and mitochondria exposed to tert-butylhydroperoxide (TBH). Our results show that mtDNA ssb induced by TBH are independent of lipid peroxidation and dependent on the presence of iron and of hydroxyl free radicals. These data contribute to the definition of the mechanisms whereby mtDNA ssb are induced and provide possible molecular targets for the prevention of this kind of damage in vivo. (C) 2003 Elsevier Science B.V. and Mitochondria Research Society. All rights reserved.
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