Haemostatic abnormalities may occur in 1-2% of patients treated with L-asparaginase. Here, we present the second case of a myocardial infarction, developing in a patient with acute lymphoblastic leukemia (ALL), in the course of L-asparaginase treatment. In our patient and in the only one reported case from the literature, a recent exposure to vincristine and daunorubicin was also reported, but induction chemotherapy program was completed as scheduled, with the only withdrawal of L-asparaginase. Myocardial infarction should be included in the list of thrombotic complications possibly associated with L-asparaginase treatment, or with a combination of L-asparaginase and vinca alkaloids/anthracycline.

Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy / Saviola, A; Luppi, Mario; Potenza, Leonardo; Morselli, M; Bresciani, P; Ferrari, Alberto; Riva, Giovanni; Torelli, Giuseppe. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - STAMPA. - 72:1(2004), pp. 71-72. [10.1046/j.0902-4441.2004.00173.x]

Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy

LUPPI, Mario;POTENZA, Leonardo;FERRARI, Alberto;RIVA, Giovanni;TORELLI, Giuseppe
2004

Abstract

Haemostatic abnormalities may occur in 1-2% of patients treated with L-asparaginase. Here, we present the second case of a myocardial infarction, developing in a patient with acute lymphoblastic leukemia (ALL), in the course of L-asparaginase treatment. In our patient and in the only one reported case from the literature, a recent exposure to vincristine and daunorubicin was also reported, but induction chemotherapy program was completed as scheduled, with the only withdrawal of L-asparaginase. Myocardial infarction should be included in the list of thrombotic complications possibly associated with L-asparaginase treatment, or with a combination of L-asparaginase and vinca alkaloids/anthracycline.
2004
72
1
71
72
Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy / Saviola, A; Luppi, Mario; Potenza, Leonardo; Morselli, M; Bresciani, P; Ferrari, Alberto; Riva, Giovanni; Torelli, Giuseppe. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - STAMPA. - 72:1(2004), pp. 71-72. [10.1046/j.0902-4441.2004.00173.x]
Saviola, A; Luppi, Mario; Potenza, Leonardo; Morselli, M; Bresciani, P; Ferrari, Alberto; Riva, Giovanni; Torelli, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/4788
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