To understand the morphological substrate of the nicotine effect on nigral FGF-2 expression, a stereological analysis of FGF-2 immunoreactive neuronal and glial profiles has been performed in the substantia nigra of the rat after acute intermittent nicotine treatment. The major finding of this paper is the demonstration that this type of nicotine treatment produces a significant reduction in the total number of nuclear FGF-2 immunoreactive astroglial profiles in the substantia nigra. A parallel analysis of nigral FGF-1 and FGF-5 immunoreactivities showed no effect of this type of nicotine treatment. The results may be explained by an inhibition of FGF-2 synthesis in a subpopulation of nigral astroglia by nicotinic receptor activation, favouring a reduction of astroglial neurotrophism in the substantia nigra. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Acute intermittent nicotine treatment produces a reduction in the total number of FGF-2 immunoreactive astroglial cells in the substantia nigra of the rat: a stereological analysis / Liu, Fl; Fuxe, K; Belluardo, N; Leo, Giuseppina; Agnati, Luigi Francesco; Aguirre, Ja. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 355:3(2004), pp. 181-184. [10.1016/j.neulet.2003.10.077]

Acute intermittent nicotine treatment produces a reduction in the total number of FGF-2 immunoreactive astroglial cells in the substantia nigra of the rat: a stereological analysis

LEO, Giuseppina;AGNATI, Luigi Francesco;
2004

Abstract

To understand the morphological substrate of the nicotine effect on nigral FGF-2 expression, a stereological analysis of FGF-2 immunoreactive neuronal and glial profiles has been performed in the substantia nigra of the rat after acute intermittent nicotine treatment. The major finding of this paper is the demonstration that this type of nicotine treatment produces a significant reduction in the total number of nuclear FGF-2 immunoreactive astroglial profiles in the substantia nigra. A parallel analysis of nigral FGF-1 and FGF-5 immunoreactivities showed no effect of this type of nicotine treatment. The results may be explained by an inhibition of FGF-2 synthesis in a subpopulation of nigral astroglia by nicotinic receptor activation, favouring a reduction of astroglial neurotrophism in the substantia nigra. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
2004
355
3
181
184
Acute intermittent nicotine treatment produces a reduction in the total number of FGF-2 immunoreactive astroglial cells in the substantia nigra of the rat: a stereological analysis / Liu, Fl; Fuxe, K; Belluardo, N; Leo, Giuseppina; Agnati, Luigi Francesco; Aguirre, Ja. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 355:3(2004), pp. 181-184. [10.1016/j.neulet.2003.10.077]
Liu, Fl; Fuxe, K; Belluardo, N; Leo, Giuseppina; Agnati, Luigi Francesco; Aguirre, Ja
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/4720
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