EnglishThe invention provides a method of treating a .beta.-lactam-antibiotic-resistant bacterial infection with a combination of a .beta.-lactamanalog (acylaminomethaneboronic acid deriv.). The invention also provides a method of inhibiting a .beta.-lactamase comprising contacting the .beta.-lactamase with a .beta.-lactamanalog. Finally, the invention provides compds. which are .beta.-lactamanalogs and compns. contg. .beta.-lactam analogs.
Acetamidomethaneboronic acids bearing the R1 side chains of beta-lactams as inhibitors of beta-lactamase enzymes / L. C., Blaszczak; Caselli, Emilia; Prati, Fabio; B. K., Shoichet. - .
| Data di concessione: | 2002 | |
| Titolo: | Acetamidomethaneboronic acids bearing the R1 side chains of beta-lactams as inhibitors of beta-lactamase enzymes | |
| Autore/i: | L. C., Blaszczak; Caselli, Emilia; Prati, Fabio; B. K., Shoichet | |
| Autore/i UNIMORE: | ||
| Abstract: | The invention provides a method of treating a .beta.-lactam-antibiotic-resistant bacterial infection with a combination of a .beta.-lactamanalog (acylaminomethaneboronic acid deriv.). The invention also provides a method of inhibiting a .beta.-lactamase comprising contacting the .beta.-lactamase with a .beta.-lactamanalog. Finally, the invention provides compds. which are .beta.-lactamanalogs and compns. contg. .beta.-lactam analogs. | |
| Handle: | http://hdl.handle.net/11380/467711 | |
| Enti collegati: | Northwestern University - Chicago (USA) | |
| Rilevanza: | Internazionale | |
| Numero di deposito: | PTC WO 02/22137 | |
| Tipologia | Brevetto |
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