EnglishThe invention provides a method of treating a .beta.-lactam-antibiotic-resistant bacterial infection with a combination of a .beta.-lactamanalog (acylaminomethaneboronic acid deriv.). The invention also provides a method of inhibiting a .beta.-lactamase comprising contacting the .beta.-lactamase with a .beta.-lactamanalog. Finally, the invention provides compds. which are .beta.-lactamanalogs and compns. contg. .beta.-lactam analogs.
| Data di concessione: | 2002 |
| Titolo: | Acetamidomethaneboronic acids bearing the R1 side chains of beta-lactams as inhibitors of beta-lactamase enzymes |
| Inventore del brevetto: | L. C. BLASZCZAK; E. CASELLI; F. PRATI; B. K. SHOICHET |
| Autori: | |
| Abstract: | The invention provides a method of treating a .beta.-lactam-antibiotic-resistant bacterial infection with a combination of a .beta.-lactamanalog (acylaminomethaneboronic acid deriv.). The invention also provides a method of inhibiting a .beta.-lactamase comprising contacting the .beta.-lactamase with a .beta.-lactamanalog. Finally, the invention provides compds. which are .beta.-lactamanalogs and compns. contg. .beta.-lactam analogs. |
| Handle: | http://hdl.handle.net/11380/467711 |
| Titolare del brevetto: | Northwestern University - Chicago (USA) |
| Rilevanza: | internazionale |
| Numero di deposito: | PTC WO 02/22137 |
| Appare nelle tipologie: | Brevetto |
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