An hydroxyapatite (HA) cylindrical chamber, containing a vessel pedicle surrounded by autologous bone and/or HA spherules, was placed in each medial right thigh of 15 New Zealand male rabbits for 3 months. Results show the displacement of chambers from the original position, several new formed blood vessels, erosion of the bone graft, with living osteocytes inside, and a little osteoclast aggression of HA spherules. New bone has formed both on bone graft and HA spherules, whereas no bone formation was detected when HA spherules were the only graft used. In conclusion, the results confirm the osteoconductive features of the used HA, highlight the effectiveness of the HA chamber and some critical aspects which can be improved to obtain the best effects.
An HA-chamber for biomaterial evaluations: first results / Zaffe, Davide; R., Adani; A., Ravaglioli; A., Kraiewski; M., Mazzocchi. - STAMPA. - (2001), pp. 266-272. (Intervento presentato al convegno 7th Meeting and Seminar on Ceramic, Cells and Tissues : Annual Conferences, Biomimetic Engineering a new role for ceramics tenutosi a Faenza RA, Italia nel 13-15 Giugno 2001).
An HA-chamber for biomaterial evaluations: first results
ZAFFE, Davide;
2001
Abstract
An hydroxyapatite (HA) cylindrical chamber, containing a vessel pedicle surrounded by autologous bone and/or HA spherules, was placed in each medial right thigh of 15 New Zealand male rabbits for 3 months. Results show the displacement of chambers from the original position, several new formed blood vessels, erosion of the bone graft, with living osteocytes inside, and a little osteoclast aggression of HA spherules. New bone has formed both on bone graft and HA spherules, whereas no bone formation was detected when HA spherules were the only graft used. In conclusion, the results confirm the osteoconductive features of the used HA, highlight the effectiveness of the HA chamber and some critical aspects which can be improved to obtain the best effects.
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