OBJECTIVE: To identify accurately thick melanomas preoperatively by means of a combined approach based on sonography and clinical-videomicroscopic evaluation. DESIGN: Ultrasonographic thickness measurement, obtained by means of a 20-MHz B-scanner, and identification of clinical and videomicroscopic variables useful in distinguishing between thick and thin melanomas were performed on a training set of 40 melanomas. An algorithm based on echographic, clinical, and videomicroscopic criteria was constructed to develop a method for preoperative evaluation of melanoma thickness and was validated on a test set of 48 melanomas. SETTING: University medical department. PATIENTS: Eighty-eight patients affected by primary cutaneous melanoma. MAIN OUTCOME MEASURES: Sensitivity and specificity of the algorithm, with the use of sonographic, clinical, and videomicroscopic data, in thick melanoma identification. RESULTS: Echographic thickness was calculated for each lesion. On the training set, 2 clinical and 7 videomicroscopic features were identified for distinction between thick and thin melanomas: nonpalpability, central pigment network, central brown globules, and blotches were characteristic of thin melanomas; clinical regression, localized peripheral pigment network, veil, grayish polygonal areas, and blood vessels were characteristic of thick ones. A coefficient was attributed to each variable and a score was obtained for each lesion. The algorithm, developed for preoperative thickness prediction, was validated on the test set, enabling the distinction of thick melanomas with an 86.7% sensitivity and a 100% specificity. CONCLUSION: The correct classification of all thin melanomas as such renders this approach suitable in clinical practice.
Pre-operative melanoma thickness determination by means of 20 MHz sonography and videomicroscopy / Pellacani, Giovanni; Martella, A; Seidenari, S.. - In: ARCHIVES OF DERMATOLOGY. - ISSN 0003-987X. - STAMPA. - 139(3)(2001), pp. 293-298.
|Data di pubblicazione:||2001|
|Titolo:||Pre-operative melanoma thickness determination by means of 20 MHz sonography and videomicroscopy|
|Autore/i:||Pellacani, Giovanni; Martella, A; Seidenari, S.|
|Citazione:||Pre-operative melanoma thickness determination by means of 20 MHz sonography and videomicroscopy / Pellacani, Giovanni; Martella, A; Seidenari, S.. - In: ARCHIVES OF DERMATOLOGY. - ISSN 0003-987X. - STAMPA. - 139(3)(2001), pp. 293-298.|
|Tipologia||Articolo su rivista|
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