There is abundant experimental evidence that melanocortins (ACTH-MSH peptides) and opioids modulate in a usually opposive way many functions not only in the central nervous system (neuronal firing, adenylate cyclate activity, Ca++ uptake into synaptosomes, pain sensitivity, body temperature, sexual behavior, memory), but also at the peripheral level.
Evidence that melanocortins are physiological antagonists of opioids / Bertolini, A., Poggioli, R., Vergoni, A.V., Castelli, M., Guarini, S. - In: CENTRAL ACTIONS OF ACTH AND RELATED PEPTIDES / D. DE WIED; W. FERRARI.. - STAMPA. - BERLIN/ HEIDELBERG : David De Wied, William Ferrari, 1986. - ISBN 3540963677. - pp. 207-222
Evidence that melanocortins are physiological antagonists of opioids
BERTOLINI, Alfio;POGGIOLI, Rosanna;VERGONI, Anna Valeria;CASTELLI, Mario;GUARINI, Salvatore
1986
Abstract
There is abundant experimental evidence that melanocortins (ACTH-MSH peptides) and opioids modulate in a usually opposive way many functions not only in the central nervous system (neuronal firing, adenylate cyclate activity, Ca++ uptake into synaptosomes, pain sensitivity, body temperature, sexual behavior, memory), but also at the peripheral level.
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