There is abundant experimental evidence that melanocortins (ACTH-MSH peptides) and opioids modulate in a usually opposive way many functions not only in the central nervous system (neuronal firing, adenylate cyclate activity, Ca++ uptake into synaptosomes, pain sensitivity, body temperature, sexual behavior, memory), but also at the peripheral level.
Evidence that melanocortins are physiological antagonists of opioids / Bertolini, Alfio; Poggioli, Rosanna; Vergoni, Anna Valeria; Castelli, Mario; Guarini, Salvatore. - STAMPA. - 4:(1986), pp. 207-222.
Evidence that melanocortins are physiological antagonists of opioids
BERTOLINI, Alfio;POGGIOLI, Rosanna;VERGONI, Anna Valeria;CASTELLI, Mario;GUARINI, Salvatore
1986
Abstract
There is abundant experimental evidence that melanocortins (ACTH-MSH peptides) and opioids modulate in a usually opposive way many functions not only in the central nervous system (neuronal firing, adenylate cyclate activity, Ca++ uptake into synaptosomes, pain sensitivity, body temperature, sexual behavior, memory), but also at the peripheral level.
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