Data from different laboratories have recently indicated that Cup is a multi-functional protein acting both during Drosophila ovary development and early embryogenesis. Cup directly and/or indirectly affects the activity of different mRNAs and proteins to achieve a broad range of biological functions: (1) Cup interacts with Nanos to promote maintenance and survival of the female germ-line stem cells; (2) it binds eIF4E and 3'-UTR-bound factors to repress translation of oskar and nanos mRNAs; (3) it interacts genetically with eIF4E to control translation initiation during ovary development and growth; (4) it may play a role in the control of the phosphorylation status of eIF4E within the developing ovary; finally, (5) it possesses nucleo-cytoplasmic shuttling properties thus pointing to a still uncharacterized function in the cell nucleus. A multi-disciplinary approach, ranging from genetics to proteomics, will be required to shed light on the diverse molecular mechanisms involving Cup and the growing family of its specific interactors.

A cup full of functions / Piccioni, F.; Zappavigna, Vincenzo; Verrotti, A.. - In: RNA BIOLOGY. - ISSN 1547-6286. - STAMPA. - 2:(2005), pp. 125-128.

A cup full of functions

ZAPPAVIGNA, Vincenzo;
2005

Abstract

Data from different laboratories have recently indicated that Cup is a multi-functional protein acting both during Drosophila ovary development and early embryogenesis. Cup directly and/or indirectly affects the activity of different mRNAs and proteins to achieve a broad range of biological functions: (1) Cup interacts with Nanos to promote maintenance and survival of the female germ-line stem cells; (2) it binds eIF4E and 3'-UTR-bound factors to repress translation of oskar and nanos mRNAs; (3) it interacts genetically with eIF4E to control translation initiation during ovary development and growth; (4) it may play a role in the control of the phosphorylation status of eIF4E within the developing ovary; finally, (5) it possesses nucleo-cytoplasmic shuttling properties thus pointing to a still uncharacterized function in the cell nucleus. A multi-disciplinary approach, ranging from genetics to proteomics, will be required to shed light on the diverse molecular mechanisms involving Cup and the growing family of its specific interactors.
2
125
128
A cup full of functions / Piccioni, F.; Zappavigna, Vincenzo; Verrotti, A.. - In: RNA BIOLOGY. - ISSN 1547-6286. - STAMPA. - 2:(2005), pp. 125-128.
Piccioni, F.; Zappavigna, Vincenzo; Verrotti, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/460870
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