The interplay between dopamine and glutamate appears to be relevant in the etiopathology of schizophrenia. Although currently used antipsychotics do not interact with glutamatergic receptors, previous results have demonstrated that the expression profile of ionotropic glutamate receptors can be regulated by drugs such as haloperidol or clozapine. In the present investigation, the mRNA levels for NMDA and AMPA receptor subunits were measured after chronic treatment with the novel antipsychotic agent Seroquel (quetiapine fumarate, quetiapine) as compared to haloperidol and clozapine. Similarly to the prototype atypical clozapine, quetiapine reduced the mRNA expression for NR-1 and NR-2C, two NMDA forming subunits, in the nucleus accumbens. Furthermore, quetiapine, but not haloperidol or clozapine, increased the hippocampal expression for the AMPA subunits GluR-B and GluR-C. The differences between classical and atypical antipsychotics, as well as among the novel agents, might be relevant for specific aspects of their therapeutic activity and could provide valuable information for the role of glutamate in specific symptoms of schizophrenia.

Regulation of ionotropic glutamate receptors in the rat brain in response to the atypical antipsychotic seroquel (quetiapine fumarate). / Tascedda, Fabio; E., Lovati; Blom, Johanna Maria Catharina; P., Muzzioli; Brunello, Nicoletta; G., Racagni; M. A., Riva. - In: NEUROPSYCHOPHARMACOLOGY. - ISSN 0893-133X. - STAMPA. - 21(2):(1999), pp. 17-211.

Regulation of ionotropic glutamate receptors in the rat brain in response to the atypical antipsychotic seroquel (quetiapine fumarate). .

TASCEDDA, Fabio;BLOM, Johanna Maria Catharina;BRUNELLO, Nicoletta;
1999

Abstract

The interplay between dopamine and glutamate appears to be relevant in the etiopathology of schizophrenia. Although currently used antipsychotics do not interact with glutamatergic receptors, previous results have demonstrated that the expression profile of ionotropic glutamate receptors can be regulated by drugs such as haloperidol or clozapine. In the present investigation, the mRNA levels for NMDA and AMPA receptor subunits were measured after chronic treatment with the novel antipsychotic agent Seroquel (quetiapine fumarate, quetiapine) as compared to haloperidol and clozapine. Similarly to the prototype atypical clozapine, quetiapine reduced the mRNA expression for NR-1 and NR-2C, two NMDA forming subunits, in the nucleus accumbens. Furthermore, quetiapine, but not haloperidol or clozapine, increased the hippocampal expression for the AMPA subunits GluR-B and GluR-C. The differences between classical and atypical antipsychotics, as well as among the novel agents, might be relevant for specific aspects of their therapeutic activity and could provide valuable information for the role of glutamate in specific symptoms of schizophrenia.
21(2)
17
211
Regulation of ionotropic glutamate receptors in the rat brain in response to the atypical antipsychotic seroquel (quetiapine fumarate). / Tascedda, Fabio; E., Lovati; Blom, Johanna Maria Catharina; P., Muzzioli; Brunello, Nicoletta; G., Racagni; M. A., Riva. - In: NEUROPSYCHOPHARMACOLOGY. - ISSN 0893-133X. - STAMPA. - 21(2):(1999), pp. 17-211.
Tascedda, Fabio; E., Lovati; Blom, Johanna Maria Catharina; P., Muzzioli; Brunello, Nicoletta; G., Racagni; M. A., Riva
File in questo prodotto:
File Dimensione Formato  
Regulation of Ionotropic Glutamate Receptors.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 305.31 kB
Formato Adobe PDF
305.31 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/459709
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 45
social impact