The effect of ring substituents on the cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to β-lactams has been investigated. A variety of aziridines with different substituents and stereochemistry has been synthesized and subjected to carbonylation. The ring expansion to β-lactam takes place in the absence of an electron-withdrawing substituent and higher yields are always obtained for cis-aziridines. Moreover, the regioselectivity of the reaction is affected by the nature of substituents at ring carbon atoms

On the Efffect of Ring Substituent in the Carbonylation of Aziridines / Davoli, Paolo; Forni, Arrigo; Moretti, Irene; Torre, Giovanni; Prati, Fabio. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 57:(2001), pp. 1801-1812.

On the Efffect of Ring Substituent in the Carbonylation of Aziridines

DAVOLI, Paolo;FORNI, Arrigo;MORETTI, Irene;TORRE, Giovanni;PRATI, Fabio
2001

Abstract

The effect of ring substituents on the cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to β-lactams has been investigated. A variety of aziridines with different substituents and stereochemistry has been synthesized and subjected to carbonylation. The ring expansion to β-lactam takes place in the absence of an electron-withdrawing substituent and higher yields are always obtained for cis-aziridines. Moreover, the regioselectivity of the reaction is affected by the nature of substituents at ring carbon atoms
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On the Efffect of Ring Substituent in the Carbonylation of Aziridines / Davoli, Paolo; Forni, Arrigo; Moretti, Irene; Torre, Giovanni; Prati, Fabio. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 57:(2001), pp. 1801-1812.
Davoli, Paolo; Forni, Arrigo; Moretti, Irene; Torre, Giovanni; Prati, Fabio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/457196
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