Baker's yeast reduces 1,1,1-trifluoro-2,4-pentanedione with high regio- and enantio-selectivity to give (S)-5,5,5-trifluoro-4-hydroxy-2-pentanone. The enantiomeric excess was determined by Mosher's method and the absolute configuration was established by correlation with ethyl (R)-(+)-4,4,4-trifluoro-3-hydroxybutanoate.
Enantioselective Synthesis of (S)-(Ð)-5,5,5-Trifluoro-4-Hydroxy-2-Pentanone by Baker's Yeast Reduction / Bucciarelli, Maria; Forni, Arrigo; Moretti, Irene; Prati, Fabio; Torre, Giovanni. - In: GAZZETTA CHIMICA ITALIANA. - ISSN 0016-5603. - STAMPA. - 120:(1990), pp. 99-99.