The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129G, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole-cell pertussis component-diphtheria-tetanus vaccine. Four hundred eighty infants were enrolled into this prospective, multicenter, double-blind study. Each infant was randomly given three doses of one of the two vaccines at 2, 4, and 6 months of age. Both local and systemic adverse reactions, reported within 48 hours and 7 days of each injection, were less frequent after the acellular vaccine than after the whole-cell vaccine. The enzyme-linked immunosorbent assay titers to pertussis toxin, filamentous hemagglutinin, and pertactin, as well as the pertussis toxin-neutralizing titer measured by the Chinese hamster ovary cell assay, were significantly higher after the acellular vaccine was given. Both vaccines induced adequate levels of anti-diphtheria and anti-tetanus antibodies. We conclude that the recombinant acellular pertussis vaccine produces fewer reactions than the whole-cell vaccine and provides a high antibody response against the antigens of Bordetella pertussis involved in bacterial adhesion and systemic toxic effects.
|Anno di pubblicazione:||1994|
|Titolo:||Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine.|
|Autore/i:||PODDA A.; CARAPELLA DE LUCA E.; CONTU B.; FURLAN R.; MAIDA A.; MOIRAGHI A.; STRAMARE D.; TITONE L.; UXA F.; DI PISA F.; S. PEPPOLONI; NENCIONI L.; RAPPUOLI R. AND THE ITALIAN MULTICENTER GROUP FOR THE STUDY OF RECOMBINANT ACELLULAR PERTUSSIS VACCINE|
|Codice identificativo ISI:||WOS:A1994NQ52100014|
|Codice identificativo Scopus:||2-s2.0-0028232732|
|Tipologia||Articolo su rivista|
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