EnglishThe simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway. Utilizing monoclonal antibodies anti-Tn antigen (HB-Tn1), anti-sialosyl-Tn antigen (HB-STn1), anti-T antigen (HB-T1) and the biotinylated Amaranthus caudatus agglutinin (ACA), we have investigated the expression of the simple mucin-type carbohydrate antigens in hereditary nonpolyposis colorectal cancer (HNPCC, 15 cases) compared with sporadic colorectal cancer (CRC, 60 cases) and normal colonic mucosa (30 cases). A variable positivity of Tn, sialosyl-Tn, T and the cryptic sialylated form of this latter antigen was encountered in both HNPCC and sporadic CRC cases, in addition, in normal colonic mucosa a constant reactivity was encountered only for Tn and the cryptic sialylated form of T, while negative results were always obtained for sialosyl-Tn and T antigens. Statistical analysis, performed using a Chi-square test, showed significantly lower (P = 0.037) expression of sialosyl-Tn and higher (P = 0.022) expression of T in HNPCC than in sporadic CRC, suggesting a greater presence of beta 1, 3 galactosyltransferase activity in HNPCC than in sporadic CRC. We were unable to identify a peculiar phenotype for HNPCC with simultaneous evaluation of reactivity for HB-Tn1, HB-STn1, HB-T1 and ACA, the biological significance of the preferential expression of T antigen in HNPCC remains to be investigated.
Detection of Tn, sialyn-Tn and T antigens in HNPCC / G., Giuffrè; E., Vitarelli; G., Tuccari; PONZ DE LEON, Maurizio; G., Barresi. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - STAMPA. - 429(1996), pp. 345-352.
| Data di pubblicazione: | 1996 | |
| Titolo: | Detection of Tn, sialyn-Tn and T antigens in HNPCC | |
| Autore/i: | G., Giuffrè; E., Vitarelli; G., Tuccari; PONZ DE LEON, Maurizio; G., Barresi | |
| Autore/i UNIMORE: | ||
| Rivista: | ||
| Volume: | 429 | |
| Pagina iniziale: | 345 | |
| Pagina finale: | 352 | |
| Codice identificativo ISI: | WOS:A1996VZ67400004 | |
| Codice identificativo Scopus: | 2-s2.0-0029750594 | |
| Codice identificativo Pubmed: | 8982378 | |
| Citazione: | Detection of Tn, sialyn-Tn and T antigens in HNPCC / G., Giuffrè; E., Vitarelli; G., Tuccari; PONZ DE LEON, Maurizio; G., Barresi. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - STAMPA. - 429(1996), pp. 345-352. | |
| Tipologia | Articolo su rivista |
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