Generalized gastrointestinal juvenile polyposis is a rare form of diffuse polyposis in which cancer infrequently develops. A clinical case is described in which gastric polyps showed a variety of histological features, including both in situ and invasive adenocarcinoma. Many mixed lesions were observed, confirming a morphological sequence already documented in colorectal tumorigenesis but still undefined in gastric tumors. The patient seems strongly predisposed to gastric cancer, presumably on a genetic basis, because he developed a malignancy in a hyperplastic juvenile polyp, usually not considered a precancerous lesion. There is no doubt that cases like this may be important for accurate genetic evaluation and biological characterization.

Generalized juvenile polyposis with mixed pattern and gastric cancer / R., Sassatelli; G., Bertoni; L., Serra; G., Bedogni; PONZ DE LEON, Maurizio. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 104(1993), pp. 910-915.

Generalized juvenile polyposis with mixed pattern and gastric cancer

PONZ DE LEON, Maurizio
1993

Abstract

Generalized gastrointestinal juvenile polyposis is a rare form of diffuse polyposis in which cancer infrequently develops. A clinical case is described in which gastric polyps showed a variety of histological features, including both in situ and invasive adenocarcinoma. Many mixed lesions were observed, confirming a morphological sequence already documented in colorectal tumorigenesis but still undefined in gastric tumors. The patient seems strongly predisposed to gastric cancer, presumably on a genetic basis, because he developed a malignancy in a hyperplastic juvenile polyp, usually not considered a precancerous lesion. There is no doubt that cases like this may be important for accurate genetic evaluation and biological characterization.
104
910
915
Generalized juvenile polyposis with mixed pattern and gastric cancer / R., Sassatelli; G., Bertoni; L., Serra; G., Bedogni; PONZ DE LEON, Maurizio. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 104(1993), pp. 910-915.
R., Sassatelli; G., Bertoni; L., Serra; G., Bedogni; PONZ DE LEON, Maurizio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/456955
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