Generalized gastrointestinal juvenile polyposis is a rare form of diffuse polyposis in which cancer infrequently develops. A clinical case is described in which gastric polyps showed a variety of histological features, including both in situ and invasive adenocarcinoma. Many mixed lesions were observed, confirming a morphological sequence already documented in colorectal tumorigenesis but still undefined in gastric tumors. The patient seems strongly predisposed to gastric cancer, presumably on a genetic basis, because he developed a malignancy in a hyperplastic juvenile polyp, usually not considered a precancerous lesion. There is no doubt that cases like this may be important for accurate genetic evaluation and biological characterization.

Generalized juvenile polyposis with mixed pattern and gastric cancer / R., Sassatelli; G., Bertoni; L., Serra; G., Bedogni; PONZ DE LEON, Maurizio. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 104(1993), pp. 910-915.

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