A 66–year–old man suffered from a drug–resistant, leftsided headache with autonomic signs, triggered by the supine position. The acromegalic facies initially suggested a possible increase in basal plasma levels of GH, but routine haematological controls excluded abnormal values of GH. Cerebral and facial CT scan and MRI did not detect any alterations in the nasal sinuses, except for a mucous cyst. Surgical ablation of the cyst did not alleviate the pain. Further endocrinological tests demonstrated an increase of IGF–1 (somatomedin C), and another MRI scan of the sellar region confirmed the presence of a pituitary macroadenoma on the left paramedian side. After an initial improvement of the symptomatology due to trans–sphenoidal ablation of a benign GH–producing macroadenoma, the headache worsened again. Pain was well correlated with the increased plasma levels of IGF–1. The patient died suddenly for myocardial infarct.

A case of a GH-producing pituitari adenoma associated with a unilateral headache with autonomic signs / N., Marzocchi; Cainazzo, Maria Michela; D., Catellani; Pini, Luigi Alberto. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - STAMPA. - 6 (3):(2005), pp. 152-155.

A case of a GH-producing pituitari adenoma associated with a unilateral headache with autonomic signs.

CAINAZZO, Maria Michela;PINI, Luigi Alberto
2005

Abstract

A 66–year–old man suffered from a drug–resistant, leftsided headache with autonomic signs, triggered by the supine position. The acromegalic facies initially suggested a possible increase in basal plasma levels of GH, but routine haematological controls excluded abnormal values of GH. Cerebral and facial CT scan and MRI did not detect any alterations in the nasal sinuses, except for a mucous cyst. Surgical ablation of the cyst did not alleviate the pain. Further endocrinological tests demonstrated an increase of IGF–1 (somatomedin C), and another MRI scan of the sellar region confirmed the presence of a pituitary macroadenoma on the left paramedian side. After an initial improvement of the symptomatology due to trans–sphenoidal ablation of a benign GH–producing macroadenoma, the headache worsened again. Pain was well correlated with the increased plasma levels of IGF–1. The patient died suddenly for myocardial infarct.
6 (3)
152
155
A case of a GH-producing pituitari adenoma associated with a unilateral headache with autonomic signs / N., Marzocchi; Cainazzo, Maria Michela; D., Catellani; Pini, Luigi Alberto. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - STAMPA. - 6 (3):(2005), pp. 152-155.
N., Marzocchi; Cainazzo, Maria Michela; D., Catellani; Pini, Luigi Alberto
File in questo prodotto:
File Dimensione Formato  
s10194-005-0170-5.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 52.67 kB
Formato Adobe PDF
52.67 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/456835
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 8
  • ???jsp.display-item.citation.isi??? ND
social impact