Acetylsalicylic acid (ASA; 400 mg/kg, i.p.) increased serotonin (5-HT) content in rat brain but did not modify the number or the affinity of 5-HT1A receptors in the pons and the cerebral cortex, whereas the number of cortical 5-HT2 receptors decreased significantly. 2. Pretreatment with parachlorophenylaline (100 mg/kg/day for 4 days) depleted 5-HT brain content but modified neither the serum levels of salicylates nor the 5-HT2 cortical receptor characteristics, and it abolished the antinociceptive effect of ASA, 400 mg/kg, in the first phase of the formalin test. 3. These data support the involvement of the central serotonergic system in the antinociceptive activity of ASA

Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain / Pini, Luigi Alberto; Sandrini, Maurizio; Vitale, Giovanni; Ottani, Alessandra. - In: GENERAL PHARMACOLOGY. - ISSN 0306-3623. - STAMPA. - 31:(1998), pp. 753-758.

Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain.

PINI, Luigi Alberto;SANDRINI, Maurizio;VITALE, Giovanni;OTTANI, Alessandra
1998

Abstract

Acetylsalicylic acid (ASA; 400 mg/kg, i.p.) increased serotonin (5-HT) content in rat brain but did not modify the number or the affinity of 5-HT1A receptors in the pons and the cerebral cortex, whereas the number of cortical 5-HT2 receptors decreased significantly. 2. Pretreatment with parachlorophenylaline (100 mg/kg/day for 4 days) depleted 5-HT brain content but modified neither the serum levels of salicylates nor the 5-HT2 cortical receptor characteristics, and it abolished the antinociceptive effect of ASA, 400 mg/kg, in the first phase of the formalin test. 3. These data support the involvement of the central serotonergic system in the antinociceptive activity of ASA
1998
31
753
758
Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain / Pini, Luigi Alberto; Sandrini, Maurizio; Vitale, Giovanni; Ottani, Alessandra. - In: GENERAL PHARMACOLOGY. - ISSN 0306-3623. - STAMPA. - 31:(1998), pp. 753-758.
Pini, Luigi Alberto; Sandrini, Maurizio; Vitale, Giovanni; Ottani, Alessandra
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/456818
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 16
social impact