Cloned cDNAs encoding a member of the gamma-aminobutyric acid type A receptor gamma-subunit class were isolated from rat-brain-mRNA-derived libraries. The gamma 3 mRNA is present in cortex, claustrum, caudate putamen, and some thalamic nuclei, particularly the medial geniculate nucleus, where it is the predominant gamma-subunit transcript. The gamma 3 gene is expressed at very low levels in cerebellum and hippocampus. In coexpression experiments with the alpha 1 and beta 2 subunits, gamma 3 imparts benzodiazepine binding to gamma-aminobutyric acid type A receptors and forms gamma-aminobutyric acid-gated benzodiazepine-modulated chloride channels that exhibit a larger conductance than alpha 1 beta 2 receptor channels. Furthermore, the presence of gamma 3 in place of gamma 2 in alpha 1 beta 2 gamma x receptors generates a marked decrease in the affinity of agonists while leaving the affinity of antagonists or negative modulators largely unaffected.
A third γ subunit of the gamma-aminobutyric acid type A receptor family." / Herb, A; Wisden, W; Luddens, H; Puja, Giulia; Vicini, S; AND SEEBURG, P. H.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 89:(1992), pp. 1433-1437.
Data di pubblicazione: | 1992 |
Titolo: | A third γ subunit of the gamma-aminobutyric acid type A receptor family." |
Autore/i: | Herb, A; Wisden, W; Luddens, H; Puja, Giulia; Vicini, S; AND SEEBURG, P. H. |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 89: |
Pagina iniziale: | 1433 |
Pagina finale: | 1437 |
Codice identificativo ISI: | WOS:A1992HE60600060 |
Codice identificativo Scopus: | 2-s2.0-0026515774 |
Codice identificativo Pubmed: | 1311098 |
Citazione: | A third γ subunit of the gamma-aminobutyric acid type A receptor family." / Herb, A; Wisden, W; Luddens, H; Puja, Giulia; Vicini, S; AND SEEBURG, P. H.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 89:(1992), pp. 1433-1437. |
Tipologia | Articolo su rivista |
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