The expression of bcl-2 appears to be typical ofcertain lymphoid malignancies. High levels of bcl-2 mRNAhad been found, previously, in established pre-B-cell lines.However, in fresh specimens, the peak level of bcl-2 expressionshifts to a more differentiated cell type, represented bythe long-living B lymphocytes that are found in most cases ofchronic lymphocytic leukemia. bcl-2 gene product might havea role in prolonging cell survival and, even in the absence oftranslocations, might contribute to some of the biologicfeatures that are typical of this disorder.
Bcl-2 gene expression in hematopoietic cell differentiation / M. T., Mariano; Moretti, Luigi; A., Donelli; M., Grantini; Montagnani, Giuliano; DI PRISCO, Alfredo Ubaldo; Torelli, Giuseppe; Torelli, Umberto; Narni, Franco. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 80:(1992), pp. 768-775.
Bcl-2 gene expression in hematopoietic cell differentiation.
MORETTI, Luigi;MONTAGNANI, Giuliano;DI PRISCO, Alfredo Ubaldo;TORELLI, Giuseppe;TORELLI, Umberto;NARNI, Franco
1992
Abstract
The expression of bcl-2 appears to be typical ofcertain lymphoid malignancies. High levels of bcl-2 mRNAhad been found, previously, in established pre-B-cell lines.However, in fresh specimens, the peak level of bcl-2 expressionshifts to a more differentiated cell type, represented bythe long-living B lymphocytes that are found in most cases ofchronic lymphocytic leukemia. bcl-2 gene product might havea role in prolonging cell survival and, even in the absence oftranslocations, might contribute to some of the biologicfeatures that are typical of this disorder.
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