The expression of bcl-2 appears to be typical ofcertain lymphoid malignancies. High levels of bcl-2 mRNAhad been found, previously, in established pre-B-cell lines.However, in fresh specimens, the peak level of bcl-2 expressionshifts to a more differentiated cell type, represented bythe long-living B lymphocytes that are found in most cases ofchronic lymphocytic leukemia. bcl-2 gene product might havea role in prolonging cell survival and, even in the absence oftranslocations, might contribute to some of the biologicfeatures that are typical of this disorder.

Bcl-2 gene expression in hematopoietic cell differentiation / M. T., Mariano; Moretti, Luigi; A., Donelli; M., Grantini; Montagnani, Giuliano; DI PRISCO, Alfredo Ubaldo; Torelli, Giuseppe; Torelli, Umberto; Narni, Franco. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 80:(1992), pp. 768-775.

Bcl-2 gene expression in hematopoietic cell differentiation.

MORETTI, Luigi;MONTAGNANI, Giuliano;DI PRISCO, Alfredo Ubaldo;TORELLI, Giuseppe;TORELLI, Umberto;NARNI, Franco
1992

Abstract

The expression of bcl-2 appears to be typical ofcertain lymphoid malignancies. High levels of bcl-2 mRNAhad been found, previously, in established pre-B-cell lines.However, in fresh specimens, the peak level of bcl-2 expressionshifts to a more differentiated cell type, represented bythe long-living B lymphocytes that are found in most cases ofchronic lymphocytic leukemia. bcl-2 gene product might havea role in prolonging cell survival and, even in the absence oftranslocations, might contribute to some of the biologicfeatures that are typical of this disorder.
1992
80
768
775
Bcl-2 gene expression in hematopoietic cell differentiation / M. T., Mariano; Moretti, Luigi; A., Donelli; M., Grantini; Montagnani, Giuliano; DI PRISCO, Alfredo Ubaldo; Torelli, Giuseppe; Torelli, Umberto; Narni, Franco. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 80:(1992), pp. 768-775.
M. T., Mariano; Moretti, Luigi; A., Donelli; M., Grantini; Montagnani, Giuliano; DI PRISCO, Alfredo Ubaldo; Torelli, Giuseppe; Torelli, Umberto; Narni...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/456122
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